Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …

Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …

Natural products, and especially the active ingredients found in traditional Chinese medicine
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …

The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think
about cancer treatment. Even so, for most types of cancer, only a minority of patients …

The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

Brain inflammation generally accompanies and accelerates neurodegeneration. Here we
report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses …

Immune signalling pathways convert pathogenic stimuli into cytosolic events that lead to the
resolution of infection. Upon ligand engagement, immune receptors together with their …

Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons
and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the …