Antibiotics have been regarded as the emerging contaminants because of their massive use
in humans and veterinary medicines and their persistence in the environment. The global …

CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) have become
ubiquitous approaches to control gene expression in bacteria due to their simple design and …

The scaling of organelles with cell size is thought to be exclusive to eukaryotes. Here, we
demonstrate that similar scaling relationships hold for the bacterial nucleoid. Despite the …

In the mammalian gut, bacteria compete for resources to maintain their populations, but the
factors determining their success are poorly understood. We report that the human gut …

Cell cycle progression requires the coordination of cell growth, chromosome replication and
division. Consequently, a functional cell cycle must be coupled with metabolism. However …

Bacterial morphology is a complex trait that is highly sensitive to changes in the
environment. For heterotrophic organisms, such as Escherichia coli, increases in nutrient …

Bacterial infections are increasingly resistant to antimicrobial therapy. Intense research
focus has thus been placed on identifying the mechanisms that bacteria use to resist killing …

Highlights•Bacteria are protected and shaped by membranes and a peptidoglycan
wall.•Peptidoglycan is often linked to a polysaccharide capsule and teichoic …

Peptidoglycan synthesis is an important target for antibiotics and relies on intermediates
derived from central metabolism. As a result, alterations of metabolism may affect antibiotic …

Antimicrobial resistance and impaired bone regeneration are the great challenges in
treating infected bone defects. Its recurrent and resistant nature, high incidence rate, long …