Metabolic regulation of the immune system in health and diseases: mechanisms and interventions

T Hu, CH Liu, M Lei, Q Zeng, L Li, H Tang… - Signal Transduction and …, 2024 - nature.com
Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other
metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic …

Cardiac macrophage metabolism in health and disease

BJ Kopecky, KJ Lavine - Trends in Endocrinology & Metabolism, 2024 - cell.com
Cardiac macrophages are essential mediators of cardiac development, tissue homeostasis,
and response to injury. Cell-intrinsic shifts in metabolism and availability of metabolites …

Inflammation in myocardial ischemia/reperfusion injury: underlying mechanisms and therapeutic potential

J Francisco, DP Del Re - Antioxidants, 2023 - mdpi.com
Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted,
leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of …

Advances in macrophage metabolic reprogramming in myocardial ischemia-reperfusion

F Ao-Di, L Han-Qing, W Xi-Zheng, Y Ke, G Hong-Xin… - Cellular …, 2024 - Elsevier
Acute myocardial infarction (AMI) is the leading cause of death worldwide, and reperfusion
therapy is a critical therapeutic approach to reduce myocardial ischemic injury and minimize …

Immuno‐Nanocomplexes Target Heterogenous Network of Inflammation and Immunity in Myocardial Infarction

F Su, W Ye, Y Shen, Y Xie, C Zhang, Q Zhang… - Advanced …, 2024 - Wiley Online Library
Despite the proceeds in the management of acute myocardial infarction (AMI), the current
therapeutic landscape still suffers from limited success in the clinic. Exaggerated …

Macrophage mediators and mechanisms in cardiovascular disease

P Schelemei, E Wagner, FSR Picard… - The FASEB …, 2024 - Wiley Online Library
Macrophages are major players in myocardial infarction (MI) and atherosclerosis, two major
cardiovascular diseases (CVD). Atherosclerosis is caused by the buildup of cholesterol‐rich …

Weighted gene co-expression network analysis and single-cell sequence analysis uncover immune landscape and reveal hub genes of necroptosis in macrophages …

X Ma, J Xie, B Li, H Shan, Z Jia, W Liu, Y Dong… - International …, 2024 - Elsevier
Myocardial ischaemia–reperfusion injury (MIRI) caused by the treatment of acute myocardial
infarction (AMI) is the primary cause of severe ventricular remodelling, heart failure (HF), and …

Immunometabolism in atherosclerotic disorders

AJ Fleetwood, J Noonan, N La Gruta… - Nature Cardiovascular …, 2024 - nature.com
Cardiovascular diseases (CVDs), including atherosclerosis, myocardial infarction and heart
failure, are the leading causes of morbidity and mortality worldwide. Emerging evidence …

[HTML][HTML] Antihypertensive Potential of Pistacia lentiscus var. Chia: Molecular Insights and Therapeutic Implications

P Efentakis, L Symeonidi, DD Gianniou… - Nutrients, 2024 - mdpi.com
Background: Hypertension poses a significant global health burden and is associated with
cardiovascular morbidity. Chios mastic gum (CMG), derived from Pistacia lentiscus var …

Nanoparticle‐based therapeutic strategies for mitochondrial dysfunction in cardiovascular disease

I Suzuki, H Xing, J Giblin, A Ashraf… - Journal of Biomedical …, 2024 - Wiley Online Library
Although cardiovascular diseases (CVD) are the leading cause of global mortality, there is a
lack of therapies that target and revert underlying pathological processes. Mitochondrial …