Tumors of the central nervous system (CNS) constitute approximately 2% of all
malignancies. Although relatively rare, the associated morbidity and mortality and the …

Neuropilin-1 and Neuropilin-2 form a small family of plasma membrane spanning receptors
originally identified by the binding of semaphorin and vascular endothelial growth factor …

Simple Summary Medulloblastoma is the most common malignant brain tumor in the
pediatric population. Despite the utilization of aggressive treatment modalities, including …

Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins that are involved in
nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in …

Simple Summary Dysregulation of molecular mechanisms that regulate nervous system
development may be at the origin of brain tumors. We reviewed the role of neuropilin-1 …

Triple-negative breast cancer (TNBC) presents a major challenge in the clinic due to its lack
of reliable prognostic markers and targeted therapies. Accumulating evidence strongly …

Medulloblastoma is the most common malignant brain cancer in pediatrics consisting of four
molecular subgroups, namely wingless (WNT), sonic hedgehog (SHH), Group 3, and Group …

Neuropilins are transmembrane glycoproteins that play important roles in cardiovascular
and neuronal development, as well as in immunological system regulations. NRP1 functions …

Abstract Neuropilin-1 and neuropilin-2 form a small family of transmembrane receptors,
which, due to the lack of a cytosolic protein kinase domain, act primarily as co-receptors for …

Medulloblastoma (MB) is the most common type of malignant pediatric brain tumor.
Neuropilin-1 (NRP1), encoded by the NRP1 gene, is a transmembrane glycoprotein …