Microsatellite instability (MSI) is the molecular fingerprint of a deficient mismatch repair
system. Approximately 15% of colorectal cancers (CRC) display MSI owing either to …

African Americans have the highest incidence and mortality rates of colorectal cancer (CRC)
of any ethnic group in the United States. Although some of these disparities can be …

L1 retrotransposons comprise 17% of the human genome and are its only autonomous
mobile elements. Although L1-induced insertional mutagenesis causes Mendelian disease …

The incidence of colorectal cancer (CRC) is rapidly increasing in developing countries,
especially among populations that are adopting Western-style diets. Several, but not all …

Abstract Colorectal cancer in African Americans has an increased incidence and mortality
relative to Whites. The mean age of CRC development in African Americans is younger than …

Purpose: Previous studies have shown that estrogen prevents colon cancer in
postmenopausal women, indicating a role in colorectal cancer carcinogenesis and tumor …

The incidence of colorectal cancer (CRC) is dramatically higher in African Americans (AAs)
than in Native Africans (NAs)(60: 100,000 vs.< 1: 100,000) and slightly higher than in …

BACKGROUND DNA methylation patterns differ among children and adults and play an
unambiguous role in several disease processes, particularly cancers. The origin of these …

Several studies have proved that DNA methylation affects regulation of gene expression and
development. Epigenome-wide studies have reported variation in methylation patterns …

The circadian timing system drives daily rhythmic changes in drug metabolism and controls
rhythmic events in cell cycle, DNA repair, apoptosis, and angiogenesis in both normal tissue …