Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

Tissue-resident macrophage populations constitute a mosaic of phenotypes, yet how their
metabolic states link to the range of phenotypes and functions in vivo is still poorly defined …

Obesity is associated with the development of various complications, including diabetes,
atherosclerosis, and an increased risk for infections, driven by dysfunctional innate immune …

Efficacy of cancer vaccines remains low and mechanistic understanding of antigen
presenting cell function in cancer may improve vaccine design and outcomes. Here, we …

Pathological conditions associated with dysfunctional wound healing are characterized by
impaired remodelling of extracellular matrix (ECM), increased macrophage infiltration, and …

Introduction Aging increases the risk of atherosclerotic vascular disease and its
complications. Macrophages are pivotal in the pathogenesis of vascular aging, driving …

Tobacco smoking doubles the risk of active tuberculosis (TB) and accounts for up to 20% of
all active TB cases globally. How smoking promotes lung microenvironments permissive to …

Tyrosine kinase inhibitors (TKIs) are very effective in treating chronic myelogenous leukemia
(CML), but primitive, quiescent leukemia stem cells persist as a barrier to the cure. We …

Immunometabolism has been unveiled in the last decade to play a major role in controlling
macrophage metabolism and inflammation. There has been a constant effort to understand …