Snake venom neurotoxins and lymphocyte antigen 6 (Ly6) proteins, most of the latter being
membrane tethered by a glycosylphosphatidylinositol (GPI) anchor, have a variety of …

The promise of nicotinic receptors as a therapeutic target has yet to be fully realized, despite
solid data supporting their involvement in neurological and neuropsychiatric diseases. The …

The cholinergic system modulates many biological functions, due to the widespread
distribution of cholinergic neuronal terminals, and the diffuse release of its neurotransmitter …

The discovery in higher animals of proteins from the Ly6/uPAR family, which have structural
homology with snake “three-finger” neurotoxins, has generated great interest in these …

The first toxin to give rise to the three‐finger protein (TFP) family was α‐bungarotoxin (α‐Bgt)
from Bungarus multicinctus krait venom. α‐Bgt was crucial for research on nicotinic …

Abstract Background Inhibition from GABAergic interneurons in brain circuits is a critical
component of cognitive function. This inhibition is regulated through a diverse network of …

α7 nAChRs are expressed widely throughout the brain, where they are important for
synaptic signaling, gene transcription, and plastic changes that regulate sensory processing …

Background and Purpose Nicotinic acetylcholine receptors (nAChRs) are a promising target
for development of new anticancer therapies. Here we have investigated the effects of the …

Lynx1 is a GPI‐tethered protein colocalized with nicotinic acetylcholine receptors (nAChRs)
in the brain areas important for learning and memory. Previously, we demonstrated that at …

Nicotinic receptors of the cholinergic system are ligand-gated ion channels, responding to
the excitatory neurotransmitter, acetylcholine, and the addictive component of tobacco …