More than 100 years after the discovery of human American trypanosomiasis by Carlos
Chagas, our knowledge and management of the disease are profoundly changing …

Chagas disease is a leading cause of heart disease affecting approximately 10 million
people in Latin America and elsewhere worldwide. The two major drugs available for the …

Antigen identification is an important step in the vaccine development process.
Computational approaches including deep learning systems can play an important role in …

Cruzain is the major papain-like cysteine protease of Trypanosoma cruzi, the etiological
agent causing Chagas' disease in humans in South America. Cruzain is indispensable for …

In the past ten years, studies have shown the recognition of Trypanosoma cruzi‐associated
molecular patterns by members of the Toll‐like receptor (TLR) family and demonstrated the …

Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a prototypical
neglected tropical disease. Specific immunity promotes acute phase survival. Nevertheless …

Chagas disease is major public health problem, affecting nearly 10 million people,
characterized by cardiac alterations leading to congestive heart failure and death of 20-40 …

Chagas disease is a major neglected tropical disease, transmitted predominantly by
triatomine insect vectors, but also through congenital and oral routes. While endemic in the …

Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite
Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries …

Chagas' disease is a major public health problem affecting nearly 10 million in Latin
America. Despite several experimental vaccines have shown to be immunogenic and …