We discuss new approaches to the early detection of keratoconus and recent investigations
regarding the nature of its pathophysiology. We review the current evidence for its complex …

Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone‐
shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It …

The bulk of the corneal stroma is comprised of a layered network of fibrillar collagen.
Determining the architecture of this unique structure may help us to better understand the …

We identified mutations in the VSX1 homeobox gene for two distinct inherited corneal
dystrophies; posterior polymorphous dystrophy (PPD) and keratoconus. One of the mutation …

The genetics of keratoconus. - Abstract - Europe PMC Sign in | Create an account https://orcid.org
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Keratoconus (KC) is a non-inflammatory thinning and protrusion of the cornea in which the
cornea assumes a conical shape. Complex etiology of this condition at present remains an …

Micromeres and their immediate descendants have three known developmental functions in
regularly developing sea urchins: immediately after their initial segregation, they are the …

Introduction Keratoconus (KC) is a complex, genetically heterogeneous, multifactorial
degenerative disorder that is accompanied by corneal ectasia which usually progresses …

Dysgenesis of the anterior segment of the eye delineates a spectrum of human
developmental disorders that show wide phenotypic and genetic heterogeneity. It is also …

We have generated embryonic stem (ES) cells and transgenic mice with green fluorescent
protein (GFP) inserted into the Pitx3 locus via homologous recombination. In the central …