BACKGROUND: Pragmatic trials compare the effects of different decisions in usual clinical
practice. OBJECTIVES: To develop and evaluate methods to implement simple pragmatic …

Microarrays have become a routine tool for biomedical research. Data quality assessment is
an essential part of the analysis, but it is still not easy to perform objectively or in an …

The assessment of data quality is a major concern in microarray analysis.
arrayQualityMetrics is a Bioconductor package that provides a report with diagnostic plots for …

Background High throughput RNA sequencing is a powerful approach to study gene
expression. Due to the complex multiple-steps protocols in data acquisition, extreme …

Purpose: To investigate the metabolism of synovial sarcoma (SS) and elucidate the effect of
malic enzyme 1 absence on SS redox homeostasis. Experimental Design: ME1 expression …

Background: The blood transcriptome is expected to provide a detailed picture of an
organism's physiological state with potential outcomes for applications in medical …

Background Activated TH 2 cells and eosinophils are hallmarks of the allergic inflammation
seen in patients with allergic rhinitis (AR). However, which cells activate and attract T cells …

Objective Obesity is driven by modifiable lifestyle factors whose effects may be mediated by
epigenetics. Therefore, we investigated lifestyle effects on blood DNA methylation in …

Groundwater is not only a vital resource, but also one of the largest terrestrial aquatic
ecosystems on Earth. However, to date, ecological criteria are often not considered in …

Current approaches within affinity-based proteomics are driven both by the accessibility and
availability of antigens and capture reagents, and by suitable multiplexed technologies onto …