Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon–bone healing

J Zou, W Yang, W Cui, C Li, C Ma, X Ji, J Hong… - Journal of …, 2023 - Springer
Tendon–bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator
cuff injury, are the most common soft tissue injuries. In most situations, surgical …

The pros and cons of mesenchymal stem cell-based therapies

A Musiał-Wysocka, M Kot, M Majka - Cell transplantation, 2019 - journals.sagepub.com
The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …

Human mesenchymal stem cells-current trends and future prospective

I Ullah, RB Subbarao, GJ Rho - Bioscience reports, 2015 - portlandpress.com
Stem cells are cells specialized cell, capable of renewing themselves through cell division
and can differentiate into multi-lineage cells. These cells are categorized as embryonic stem …

Manufacturing of primed mesenchymal stromal cells for therapy

JQ Yin, J Zhu, JA Ankrum - Nature biomedical engineering, 2019 - nature.com
Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …

Mesenchymal stem cells in fibrotic disease

E El Agha, R Kramann, RK Schneider, X Li, W Seeger… - Cell stem cell, 2017 - cell.com
Fibrosis is associated with organ failure and high mortality and is commonly characterized
by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in …

[HTML][HTML] Stem cell membrane-coated abiotic nanomaterials for biomedical applications

I Ferreira-Faria, S Yousefiasl, A Macário-Soares… - Journal of controlled …, 2022 - Elsevier
Nanoscale materials have been extensively employed for diagnostic and therapeutic
purposes. However, the developed nanosystems still suffer from some limitations, namely …

Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application

H Caplan, SD Olson, A Kumar, M George… - Frontiers in …, 2019 - frontiersin.org
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …

Therapeutic effects of human mesenchymal stem cell–derived microvesicles in severe pneumonia in mice

A Monsel, Y Zhu, S Gennai, Q Hao, S Hu… - American journal of …, 2015 - atsjournals.org
Rationale: Microvesicles (MVs) are anuclear fragments of cells released from the endosomal
compartment or shed from surface membranes. We and other investigators demonstrated …

[HTML][HTML] Cell or cell membrane-based drug delivery systems

S Tan, T Wu, D Zhang, Z Zhang - Theranostics, 2015 - ncbi.nlm.nih.gov
Natural cells have been explored as drug carriers for a long period. They have received
growing interest as a promising drug delivery system (DDS) until recently along with the …

Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy–a review

J Freitag, D Bates, R Boyd, K Shah, A Barnard… - BMC musculoskeletal …, 2016 - Springer
Osteoarthritis is a leading cause of pain and disability across the world. With an aging
population its prevalence is likely to further increase. Current accepted medical treatment …