Primary structure of glycans by NMR spectroscopy

C Fontana, G Widmalm - Chemical Reviews, 2023 - ACS Publications
Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

Synthesis of a glycan hairpin

G Fittolani, T Tyrikos-Ergas, A Poveda, Y Yu… - Nature Chemistry, 2023 - nature.com
The primary sequence of a biopolymer encodes the essential information for folding,
permitting to carry out sophisticated functions. Inspired by natural biopolymers, peptide and …

Natural resourced polysaccharides: Preparation, purification, structural elucidation, structure-activity relationships and regulating intestinal flora, a system review

D Han, L Yang, Q Liang, H Sun, Y Sun, G Yan… - International Journal of …, 2024 - Elsevier
Natural resourced polysaccharides (NRPs), as metabolites synthesized during activity of
organisms, widely present in animal cell membranes or plant and microbial cell walls. NRPs …

Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility

G Dorn, C Gmeiner, T de Vries, E Dedic… - Nature …, 2023 - nature.com
RNA-binding proteins (RBPs) are crucial regulators of gene expression, often composed of
defined domains interspersed with flexible, intrinsically disordered regions. Determining the …

Molecular recognition insights of sialic acid glycans by distinct receptors unveiled by NMR and molecular modeling

CO Soares, AS Grosso, J Ereño-Orbea… - Frontiers in Molecular …, 2021 - frontiersin.org
All cells are decorated with a highly dense and complex structure of glycan chains, which
are mostly attached to proteins and lipids. In this context, sialic acids are a family of nine …

Glycan Shape, Motions, and Interactions Explored by NMR Spectroscopy

G Widmalm - JACS Au, 2024 - ACS Publications
Glycans in the form of oligosaccharides, polysaccharides, and glycoconjugates are
ubiquitous in nature, and their structures range from linear assemblies to highly branched …

Modeling and simulation of bacterial outer membranes with lipopolysaccharides and capsular polysaccharides

Y Gao, G Widmalm, W Im - Journal of Chemical Information and …, 2023 - ACS Publications
Capsule is one of the common virulence factors in Gram-negative bacteria protecting
pathogens from host defenses and consists of long-chain capsular polysaccharides (CPS) …

On the Use of Strong Proton Donors as a Tool for Overcoming Line Broadening in NMR: A Comment

P Charisiadis, T Venianakis… - Magnetic …, 2024 - Wiley Online Library
Overcoming line broadening of labile protons and achieving high‐resolution NMR spectra is
crucial for the structural and conformational analysis of organic molecules. Recently, Ma et …

NMR investigations of glycan conformation, dynamics, and interactions

J Angulo, A Ardá, S Bertuzzi, A Canales… - Progress in Nuclear …, 2024 - Elsevier
Glycans are ubiquitous in nature, decorating our cells and serving as the initial points of
contact with any visiting entities. These glycan interactions are fundamental to host …

Relaxation-Assisted Magnetization Transfer Phenomena for a Sensitivity-Enhanced 2D NMR

M Novakovic, J Kim, XC Su, E Kupče… - Analytical …, 2023 - ACS Publications
2D NOESY and TOCSY play central roles in contemporary NMR. We have recently
discussed how solvent-driven exchanges can significantly enhance the sensitivity of such …