Central to the impacts of CD4 T cells, both positive in settings of infectious disease and
cancer and negative in the settings of autoimmunity and allergy, is their ability to differentiate …

Each time the virus starts a new round of expression/replication, even under effective
antiretroviral therapy (ART), the transactivator of viral transcription Tat is one of the first HIV-1 …

Adenoviral and mRNA vaccines encoding the viral spike (S) protein have been deployed
globally to contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Older …

Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection.
Virus-specific CD8+ T-cell responses have shown to be protective toward critical COVID-19 …

HIV infection is associated with an increase in the proportion of activated CD8+ memory T
cells (Tmem) that express CX3CR1, but how these cells are generated and maintained in …

Chronic HCV infection is characterized by several immunological alterations, such as the
accumulation of suppressor cells and of hyperactivated T lymphocytes. However, it is …

Introduction: Tat, a key HIV virulence protein, has been targeted for the development of a
therapeutic vaccine aimed at cART intensification. Results from phase II clinical trials in Italy …

Aging is associated with functional deficits in the naive T cell compartment, which
compromise the generation of de novo immune responses against previously …

Despite over 30 years of enormous effort and progress in the field, no preventative and/or
therapeutic vaccines against human immunodeficiency virus (HIV) are available. Here, we …

Human papillomavirus (HPV) persistent infections are associated with cervical cancer and
other HPV-related diseases and tumors. Thus, the characterization of long lasting immunity …