Therapeutic peptides: current applications and future directions

L Wang, N Wang, W Zhang, X Cheng, Z Yan… - Signal transduction and …, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

Trends in peptide drug discovery

M Muttenthaler, GF King, DJ Adams… - Nature reviews Drug …, 2021 - nature.com
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …

Macrocyclic peptides as drug candidates: recent progress and remaining challenges

AA Vinogradov, Y Yin, H Suga - Journal of the American Chemical …, 2019 - ACS Publications
Peptides as a therapeutic modality attract much attention due to their synthetic accessibility,
high degree of specific binding, and the ability to target protein surfaces traditionally …

Simple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapy

Z Liu, X Chen - Chemical Society Reviews, 2016 - pubs.rsc.org
Albumin is the most abundant circulating protein in plasma and has recently emerged as a
versatile protein carrier for drug targeting and for improving the pharmacokinetic profile of …

Current strategies in extending half-lives of therapeutic proteins

R Zaman, RA Islam, N Ibnat, I Othman, A Zaini… - Journal of controlled …, 2019 - Elsevier
Macromolecular protein and peptide therapeutics have been proven to be effective in
treating critical human diseases precisely. Thanks to biotechnological advancement, a huge …

Strategic approaches to optimizing peptide ADME properties

L Di - The AAPS journal, 2015 - Springer
Abstract Development of peptide drugs is challenging but also quite rewarding. Five
blockbuster peptide drugs are currently on the market, and six new peptides received first …

Peptidomics: A review of clinical applications and methodologies

RE Foreman, AL George, F Reimann… - Journal of Proteome …, 2021 - ACS Publications
Improvements in both liquid chromatography (LC) and mass spectrometry (MS)
instrumentation have greatly enhanced proteomic and small molecule metabolomic analysis …

Drug delivery vehicles on a nano-engineering perspective

B Felice, MP Prabhakaran, AP Rodriguez… - Materials Science and …, 2014 - Elsevier
Nanoengineered drug delivery systems (nDDS) have been successfully used as clinical
tools for not only modulation of pharmacological drug release profile but also specific …

Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival

M Cieslewicz, J Tang, JL Yu, H Cao… - Proceedings of the …, 2013 - National Acad Sciences
Most current cancer therapies focus on killing malignant cells, but these cells are often
genetically unstable and can become resistant to chemotherapy. Tumor-associated …

Designing improved active peptides for therapeutic approaches against infectious diseases

B Gomes, MT Augusto, MR Felício, A Hollmann… - Biotechnology …, 2018 - Elsevier
Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …