Abstract G‐quadruplexes (G4), found in numerous places within the human genome, are
involved in essential processes of cell regulation. Chromosomal DNA G4s are involved for …

G‐quadruplexes have attracted growing interest in recent years due to their occurrence in
vivo and their possible biological functions. In addition to being promising targets for drug …

Abstract DNA G-Quadruplexes (G4s) formed in oncogene promoters regulate transcription.
The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers …

The structure of the 68 nt sequence with G-quadruplex forming potential within the hTERT
promoter is disputed. One model features a structure with three stacked parallel G …

We report on higher-order G-quadruplex structures adopted by long promoter sequences
obtained by an iterative integrated structural biology approach. Our approach uses …

Photocleavable protecting groups (PPGs) play a pivotal role in numerous studies. They
enable controlled release of small effector molecules to induce biochemical function. The …

Many cancer-associated genes are regulated by guanine (G)-rich sequences that are
capable of refolding from the canonical duplex structure to an intrastrand G-quadruplex …

Intramolecular guanine quadruplexes (G4s) are non-canonical nucleic acid structures
formed by four guanine (G)-rich tracts that assemble into a core of stacked planar tetrads. G4 …

The folding of DNA G-quadruplexes (G4) is essential to regulate expression of oncogenes
and involves polymorphic long-lived intermediate states. G4 formation requires four G-tracts …

G-quadruplexes are nucleic acid motifs formed by stacking of guanosine-tetrad
pseudoplanes. They perform varied biological roles, and their distinctive structural features …