The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the
primary structure for the perception of sound. Along the length of the cochlear spiral is the …

The study of epigenetics has improved our understanding of mechanisms underpinning
gene‐environment interactions and is providing new insights in the pathophysiology of …

Inner ear vestibular and spiral ganglion neurons (VGNs and SGNs) are known to play
pivotal roles in balance control and sound detection. However, the molecular mechanisms …

Background Inner ear supporting cells (SCs) in the neonatal mouse cochlea are a potential
source for hair cell (HC) regeneration, but several studies have shown that the regeneration …

Sensorineural hearing loss is the most prevalent sensory deficit in humans. Most cases of
hearing loss are due to the degeneration of key structures of the sensory pathway in the …

Background Treatment response to systemic corticosteroid in asthmatic children is
heterogeneous and may be mediated by epigenetic mechanism (s). We aim to identify DNA …

Alternative splicing contributes to gene expression dynamics in many tissues, yet its role in
auditory development remains unclear. We performed whole-exome sequencing in …

The transcription factor Sox2 is both necessary and sufficient for the generation of sensory
regions of the inner ear. It regulates expression of the Notch ligand Jag1 in prosensory …

Inner ear morphogenesis requires tightly regulated epigenetic and transcriptional control of
gene expression. CHD7, an ATP-dependent chromodomain helicase DNA-binding protein …

Auditory hair cells transduce sound to the brain, and in mammals, these cells reside together
with supporting cells in the sensory epithelium of the cochlea, called the organ of Corti. To …