Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

Caspases are a family of cysteine proteases that play important roles in regulating
apoptosis. A decade of research has generated a wealth of information on the signal …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Derangements in apoptosis of liver cells are mechanistically important in the pathogenesis
of end-stage liver disease. Vulnerable hepatocytes can undergo apoptosis via an extrinsic …

Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic
transplantation, hepatic resection, and trauma. The signaling events contributing to local …

Warm and cold hepatic ischemia followed by reperfusion leads to necrotic cell death
(oncosis), which often occurs within minutes of reperfusion. Recent studies also suggest a …

This article summarizes strategies to protect the liver from injuries caused by ischemia and
reperfusion. Three different sections (ie, surgical and pharmacologic strategies and gene …

We sought to determine whether mice deficient in the proinflammatory caspase-1, which
cleaves precursors of IL-1β and IL-18, were protected against ischemic acute renal failure …

Objective: To evaluate the protective effects of ischemic preconditioning in a prospective
randomized study involving a large population of unselected patients and to identify factors …

Having recently described the injurious role of caspase-1–mediated production of the
proinflammatory cytokine IL-18 in ischemic acute renal failure (ARF), we report here on the …