The ability of the human immune system to protect against infectious disease declines with
age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune …

Once regarded as an experimental artefact, cytotoxic CD4+ T cells (CD4 CTL) are presently
recognized as a biologically relevant T cell subset with important functions in anti-viral, anti …

Understanding how decidual CD8+ T cell (CD8+ dT) cytotoxicity is regulated and how these
cells integrate the competing needs for maternal–fetal tolerance and immunity to infection is …

Flow cytometry is now accepted as an ideal technology to reveal changes in immune cell
composition and function. However, it is also an error‐prone and variable technology, which …

Simian immunodeficiency virus (SIV) insert–expressing, 68-1 rhesus cytomegalovirus
(RhCMV/SIV) vectors elicit major histocompatibility complex E (MHC-E)–and MHC-II …

INTRODUCTION Strain 68-1 rhesus cytomegalovirus (RhCMV) vaccine vectors expressing
simian immunodeficiency virus (SIV) antigens elicit immune responses that stringently …

Aging is accompanied by significant defects in immunity and compromised responses to
new, previously unencountered microbial pathogens. Most humans carry several persistent …

Cytotoxic CD4 (CD4CTX) T cells are emerging as an important component of antiviral and
antitumor immunity, but the molecular basis of their development remains poorly …

The critical role of interferons (IFNs) in mediating the innate immune response to
cytomegalovirus (CMV) infection is well established. However, in recent years the functional …

Early life adversity (ELA) increases the risk for multiple age-related diseases, such as
diabetes type 2 and cardiovascular disease. As prevalence is high, ELA poses a major and …