Antibodies to combat viral infections: development strategies and progress

G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Influenza hemagglutinin structures and antibody recognition

NC Wu, IA Wilson - Cold Spring Harbor …, 2020 - perspectivesinmedicine.cshlp.org
Hemagglutinin (HA) is most abundant glycoprotein on the influenza virus surface. Influenza
HA promotes viral entry by engaging the receptor and mediating virus–host membrane …

[PDF][PDF] Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

H Lv, NC Wu, OTY Tsang, M Yuan, RAPM Perera… - Cell reports, 2020 - cell.com
Summary The World Health Organization has declared the ongoing outbreak of COVID-19,
which is caused by a novel coronavirus SARS-CoV-2, a pandemic. There is currently a lack …

[PDF][PDF] The effect of spike mutations on SARS-CoV-2 neutralization

C Rees-Spear, L Muir, SA Griffith, J Heaney, Y Aldon… - Cell reports, 2021 - cell.com
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show
protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the …

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

AJ Greaney, TN Starr, RT Eguia, AN Loes… - PLoS …, 2022 - journals.plos.org
Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it
is unknown if antibodies elicited by infection with these variants target the same or different …

Breathing and tilting: mesoscale simulations illuminate influenza glycoprotein vulnerabilities

L Casalino, C Seitz, J Lederhofer… - ACS Central …, 2022 - ACS Publications
Influenza virus has resurfaced recently from inactivity during the early stages of the COVID-
19 pandemic, raising serious concerns about the nature and magnitude of future epidemics …

[HTML][HTML] Childhood immune imprinting to influenza A shapes birth year-specific risk during seasonal H1N1 and H3N2 epidemics

KM Gostic, R Bridge, S Brady, C Viboud… - PLoS …, 2019 - journals.plos.org
Across decades of co-circulation in humans, influenza A subtypes H1N1 and H3N2 have
caused seasonal epidemics characterized by different age distributions of cases and …

Progress towards the development of a universal influenza vaccine

WC Wang, EE Sayedahmed, S Sambhara, SK Mittal - Viruses, 2022 - mdpi.com
Influenza viruses are responsible for millions of cases globally and significantly threaten
public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 …

[HTML][HTML] A Research and Development (R&D) roadmap for influenza vaccines: Looking toward the future

KA Moore, JT Ostrowsky, AM Kraigsley, AJ Mehr… - Vaccine, 2021 - Elsevier
Improved influenza vaccines are urgently needed to reduce the burden of seasonal
influenza and to ensure a rapid and effective public-health response to future influenza …

[HTML][HTML] Current challenges in vaccinology

RB Kennedy, IG Ovsyannikova, P Palese… - Frontiers in …, 2020 - frontiersin.org
The development of vaccines, which prime the immune system to respond to future
infections, has led to global declines in morbidity and mortality from dreadful infectious …