Neuroimaging standards for research into small vessel disease—advances since 2013

M Duering, GJ Biessels, A Brodtmann, C Chen… - The Lancet …, 2023 - thelancet.com
Cerebral small vessel disease (SVD) is common during ageing and can present as stroke,
cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently …

Intracerebral haemorrhage

L Puy, AR Parry-Jones, EC Sandset… - Nature Reviews …, 2023 - nature.com
Intracerebral haemorrhage (ICH) is a dramatic condition caused by the rupture of a cerebral
vessel and the entry of blood into the brain parenchyma. ICH is a major contributor to stroke …

[HTML][HTML] Multiple cerebral hemorrhages in a patient receiving lecanemab and treated with t-PA for stroke

NJ Reish, P Jamshidi, B Stamm… - … England Journal of …, 2023 - Mass Medical Soc
Cerebral Hemorrhages after t-PA in a Patient Treated with Lecanemab A patient with mild
cognitive impairment who was treated in the extension phase of a trial of lecanemab, an …

Cerebral small vessel disease: recent advances and future directions

HS Markus, FE de Leeuw - International Journal of Stroke, 2023 - journals.sagepub.com
Cerebral small vessel disease (SVD) causes lacunar stroke and intracerebral hemorrhage,
and is the most common pathology underlying vascular cognitive impairment. Increasingly …

[HTML][HTML] Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease

Y Inoue, F Shue, G Bu, T Kanekiyo - Molecular neurodegeneration, 2023 - Springer
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Alzheimer's disease: From immunotherapy to immunoprevention

M Jucker, LC Walker - Cell, 2023 - cell.com
Recent Aβ-immunotherapy trials have yielded the first clear evidence that removing
aggregated Aβ from the brains of symptomatic patients can slow the progression of …

Progression of cerebral amyloid angiopathy: a pathophysiological framework

EA Koemans, JP Chhatwal, SJ van Veluw… - The Lancet …, 2023 - thelancet.com
Cerebral amyloid angiopathy, which is defined by cerebrovascular deposition of amyloid β,
is a common age-related small vessel pathology associated with intracerebral haemorrhage …

[HTML][HTML] Fatal iatrogenic cerebral β-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer's disease

E Solopova, W Romero-Fernandez, H Harmsen… - Nature …, 2023 - nature.com
We report the case of a 79-year-old woman with Alzheimer's disease who participated in a
Phase III randomized controlled trial called CLARITY-AD testing the experimental drug …

[HTML][HTML] Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

MG Duperron, MJ Knol, Q Le Grand, TE Evans… - Nature medicine, 2023 - nature.com
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance
imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia …

Neuroimaging in dementia: more than typical Alzheimer disease

S Haller, HR Jäger, MW Vernooij, F Barkhof - Radiology, 2023 - pubs.rsna.org
Alzheimer disease (AD) is the most common cause of dementia. The prevailing theory of the
underlying pathology assumes amyloid accumulation followed by tau protein aggregation …