DNA damage, largely owing to oxidative stress, is a leading cause of defective sperm
function. High levels of oxidative stress result in damage to sperm DNA, RNA transcripts …

In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

Reactive oxygen species (ROS) have been extensively studied as a cause of male infertility.
Excessive levels of ROS coupled with a deficiency in antioxidants can lead to oxidative …

Besides ATP production, mitochondria are key organelles in several cellular functions, such
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …

Objective To evaluate whether male fertility status and/or embryo quality during in vitro
fertilization (IVF) therapy can be predicted based on genomewide sperm deoxyribonucleic …

The effects of reactive oxygen species on male fertility are governed by the oxidative
paradox, defined by a delicate balance between oxidative stress and antioxidant capacity …

BACKGROUND Over the past few years, advances in molecular technologies have allowed
unprecedented mapping of epigenetic modifications in gametes and during early embryonic …

The accurate prediction of male fertility is of major economic importance in the animal
breeding industry. However, the results of conventional semen analysis do not always …

Infertility is a complex disorder with multiple genetic and environmental causes. Although
some specific mutations have been identified, other factors responsible for sperm defects …

STUDY QUESTION What is the sperm DNA methylation status of imprinted genes in male
partners from couples experiencing recurrent pregnancy loss (RPL)? SUMMARY ANSWER …