Applications of palladium-catalyzed C–N cross-coupling reactions

P Ruiz-Castillo, SL Buchwald - Chemical reviews, 2016 - ACS Publications
Pd-catalyzed cross-coupling reactions that form C–N bonds have become useful methods to
synthesize anilines and aniline derivatives, an important class of compounds throughout …

A comprehensive account on recent progress in pharmacological activities of benzimidazole derivatives

SR Brishty, MJ Hossain, MU Khandaker… - Frontiers in …, 2021 - frontiersin.org
Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest
among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole …

Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies

J Zhang, Y Zhang, J Wang, Y Xia, J Zhang… - Signal transduction and …, 2024 - nature.com
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Comprehensive review in current developments of benzimidazole‐based medicinal chemistry

RS Keri, A Hiremathad, S Budagumpi… - Chemical biology & …, 2015 - Wiley Online Library
The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …

Therapeutic evolution of benzimidazole derivatives in the last quinquennial period

W Akhtar, MF Khan, G Verma… - European journal of …, 2017 - Elsevier
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

Identification of novel acetylcholinesterase inhibitors designed by pharmacophore-based virtual screening, molecular docking and bioassay

C Jang, DK Yadav, L Subedi, R Venkatesan… - Scientific reports, 2018 - nature.com
In this study, pharmacophore based 3D QSAR models for human acetylcholinesterase
(AChE) inhibitors were generated, with good significance, statistical values (r2training …

Targeting protein kinases for the treatment of Alzheimer's disease: recent progress and future perspectives

Z Li, B Yin, S Zhang, Z Lan, L Zhang - European Journal of Medicinal …, 2023 - Elsevier
Alzheimer's disease (AD) is a serious neurodegenerative disease characterized by memory
impairment, mental retardation, impaired motor balance, loss of self-care and even death …

Inhibitors of c-Jun N-terminal kinases: an update

P Koch, M Gehringer, SA Laufer - Journal of medicinal chemistry, 2015 - ACS Publications
The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the
pathogenesis of various diseases. Recent advances in the development of novel inhibitors …

Applications of palladium-catalyzed C–N cross-coupling reactions in pharmaceutical compounds

R Emadi, AB Nekoo, F Molaverdi, Z Khorsandi… - RSC …, 2023 - pubs.rsc.org
C–N cross-coupling bond formation reactions have become valuable approaches to
synthesizing anilines and their derivatives, known as important chemical compounds …

Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine

OO Ajani, DV Aderohunmu, CO Ikpo… - Archiv der …, 2016 - Wiley Online Library
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …