Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

Objective: To delineate temporal and spatial dynamics of vascular smooth muscle cell
(SMC) transcriptomic changes during aortic aneurysm development in Marfan syndrome …

The transforming growth factor beta (TGF-β) is a crucial cytokine that get increasing concern
in recent years to treat human diseases. This signal controls multiple cellular responses …

Objective. The objective of this study was to investigate the involved mechanisms of
advanced glycation end product‐(AGE‐) exacerbated atherosclerosis (AS). Methods. Toll …

Background: Marfan syndrome (MFS) is associated with TGF (transforming growth factor) β–
stimulated ERK (extracellular signal-regulated kinase) activity in vascular smooth muscle …

Marfan syndrome (MFS) is a complex connective tissue disease that is primarily
characterized by cardiovascular, ocular and skeletal systems disorders. Despite its rarity …

The molecular and cellular processes leading to aortic aneurysm development in Marfan
syndrome (MFS) remain poorly understood. In this study, we examined the changes of aortic …

Background: Aortic root smooth muscle cells (SMC) develop from both the second heart field
(SHF) and neural crest. Disparate responses to disease-causing Fbn1 variants by these …