The biology and underlying mechanisms of cross-presentation of exogenous antigens on MHC-I molecules

FM Cruz, JD Colbert, E Merino… - Annual review of …, 2017 - annualreviews.org
To monitor the health of cells, the immune system tasks antigen-presenting cells with
gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides …

On the role of the immunoproteasome in protein homeostasis

M Basler, M Groettrup - Cells, 2021 - mdpi.com
Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …

The immunoproteasome‐specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis

N Althof, CC Goetzke, M Kespohl, K Voss… - EMBO molecular …, 2018 - embopress.org
Severe heart pathology upon virus infection is closely associated with the immunological
equipment of the host. Since there is no specific treatment available, current research …

Impairment of multiple mitochondrial energy metabolism pathways in the heart of Chagas disease cardiomyopathy patients

PC Teixeira, A Ducret, H Langen, E Nogoceke… - Frontiers in …, 2021 - frontiersin.org
Chagas disease cardiomyopathy (CCC) is an inflammatory dilated cardiomyopathy
occurring in 30% of the 6 million infected with the protozoan Trypanosoma cruzi in Latin …

Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it

EVA Rodríguez, CLA Furlan, FF Vernengo… - Trends in …, 2019 - cell.com
The protozoan Trypanosoma cruzi is the causative agent of Chagas' disease, endemic in
Latin America but present worldwide. Research efforts have focused on the examination of …

ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas' disease

JT Castro, R Brito, NS Hojo-Souza, B Azevedo… - npj Vaccines, 2023 - nature.com
Abstract Immunization with the Amastigote Surface Protein-2 (ASP-2) and Trans-sialidase
(TS) antigens either in the form of recombinant protein, encoded in plasmids or human …

Proteasome composition in immune cells implies special immune‐cell‐specific immunoproteasome function

K Inholz, JL Anderl, M Klawitter… - European Journal of …, 2024 - Wiley Online Library
Immunoproteasomes are a special class of proteasomes, which can be induced with IFN‐γ
in an inflammatory environment. In recent years, it became evident that certain immune cell …

The function of immunoproteasomes—an immunologists' perspective

BL van den Eshof, L Medfai, E Nolfi, M Wawrzyniuk… - Cells, 2021 - mdpi.com
Proteasomes are responsible for intracellular proteolysis and play an important role in
cellular protein homeostasis. Cells of the immune system assemble a specialized form of …

The immunoproteasome subunits LMP2, LMP7 and MECL-1 are crucial along the induction of cerebral toxoplasmosis

T French, N Israel, HP Düsedau, A Tersteegen… - Frontiers in …, 2021 - frontiersin.org
Cell survival and function critically relies on the fine-tuned balance of protein synthesis and
degradation. In the steady state, the standard proteasome is sufficient to maintain this …

Identification of candidate signature genes and key regulators associated with Trypanotolerance in the Sheko Breed

YA Mekonnen, M Gültas, K Effa, O Hanotte… - Frontiers in …, 2019 - frontiersin.org
African animal trypanosomiasis (AAT) is caused by a protozoan parasite that affects the
health of livestock. Livestock production in Ethiopia is severely hampered by AAT and …