Rna interference mediating small rna molecules

T Tuschl, S Elbashir, W Lendeckel, M Wilm… - US Patent App. 10 …, 2004 - Google Patents
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene
Silencing in many organisms by a process known as RNA interference (RNAi). Using a …

RNA interference mediated inhibition of adenosine A1 receptor (ADORA1) gene expression using short interfering RNA

K Fosnaugh, J McSwiggen - US Patent App. 10/224,005, 2003 - Google Patents
Correspondence Address: MCDONNELL BOEHNEN HULBERT &(57) ABSTRACT
BERGHOFF The present invention concerns methods and reagents useful 300 SOUTH …

RNA sequence-specific mediators of RNA interference

T Tuschl, P Zamore, P Sharp, D Bartel - US Patent App. 09/821,832, 2002 - Google Patents
The present invention relates to a Drosophila in vitro system which was used to demonstrate
that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore …

RNA sequence-specific mediators of RNA interference

T Tuschl, P Zamore, P Sharp, D Bartel - US Patent App. 10/255,568, 2003 - Google Patents
The present invention relates to a Drosophila in vitro System which was used to demonstrate
that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Further more …

RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)

D Morrissey, J McSwiggen… - US Patent App. 10 …, 2003 - Google Patents
The present invention concerns methods and reagents useful in modulating hepatitis B virus
(HBV) gene expression in a variety of applications, including use in therapeutic, diag nostic …

Methods and compositions for the specific inhibition of gene expression by double-stranded RNA

JJ Rossi, MA Behlke, D Kim - US Patent 8,084,599, 2011 - Google Patents
The invention is directed to compositions and methods for selectively reducing the
expression of a gene product from a desired target gene in a cell, as well as for treating …

RNA interference mediated treatment of Alzheimer's disease using short interfering RNA

J McSwiggen - US Patent App. 10/205,309, 2003 - Google Patents
The present invention concerns methods and reagents useful in modulating gene
expression in a variety of applications, including use in therapeutic, diagnostic, target …

Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA

YX Li, M Farrell, M Kirby - US Patent App. 10/038,984, 2002 - Google Patents
US20020114784A1 - Composition and method for in vivo and in vitro attenuation of gene
expression using double stranded RNA - Google Patents US20020114784A1 …

RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA)

J McSwiggen - US Patent App. 10/251,117, 2003 - Google Patents
US20030170891A1 - RNA interference mediated inhibition of epidermal growth factor
receptor gene expression using short interfering nucleic acid (siNA) - Google Patents …

Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs

D Brown, L Ford, R Jarvis - US Patent App. 10/298,480, 2004 - Google Patents
The present invention concerns methods and compositions involving the production or
generation of siRNA mixtures or pools capable of triggering RNA-mediated interference …