BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

Prolactin is a protein hormone of the anterior pituitary gland that was originally named for its
ability to promote lactation in response to the suckling stimulus of hungry young mammals …

Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and
neuropeptides. In this review, we examine the variability in the individual peptides produced …

Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that
colocalize three neuropeptides, kisspeptin, neurokinin B, and dynorphin, each of which has …

A unique interdisciplinary overview of the way mammals reproduce, this volume synthesizes
research done by laboratory physiologists, behaviorists, population ecologists, and animal …

An increase in pulsatile release of LHRH is essential for the onset of puberty. However, the
mechanism controlling the pubertal increase in LHRH release is still unclear. In primates the …

Corticotropin-releasing hormone (CRH) plays major roles in coordination of the stress
response and regulation of the immune/inflammatory reaction, two important functions …

Classically, 17β-estradiol (E 2) is thought to control homeostatic functions such as
reproduction, stress responses, feeding, sleep cycles, temperature regulation, and motivated …

Hypothalamic proopiomelanocortin (POMC) neurons are critical for controlling homeostatic
functions in the mammal. We used a transgenic mouse model in which the POMC neurons …

The biological regulation of appetite is currently an important topic in nutrition, since
hyperphagia has been implicated as the prime cause of obesity. Cyclical fluctuations in food …