The ability to establish behaviorally what psychological capacity an animal is deploying—to discern accurately what an animal is doing—is key to functional analyses of the brain. Our …
The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in …
DM Lovinger, Y Mateo, KA Johnson, SA Engi… - Nature Reviews …, 2022 - nature.com
Central nervous system neurons communicate via fast synaptic transmission mediated by ligand-gated ion channel (LGIC) receptors and slower neuromodulation mediated by G …
Early life stress (ELS), in the form of childhood maltreatment, abuse, or neglect, increases the risk for psychiatric sequelae later in life. The neurobiology of response to early stress …
Adaptive reward-related decision making requires accurate prospective consideration of the specific outcome of each option and its current desirability. These mental simulations are …
The multiple-memory-systems framework—that distinct types of memory are supported by distinct brain systems—has guided learning and memory research for decades. However …
The estimated values of choices, and therefore decision-making based on those values, are influenced by both the chance that the chosen items or goods can be obtained (availability) …
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are an increasingly popular approach for “remotely controlling” selected neuronal populations and …
M Malvaez, C Shieh, MD Murphy, VY Greenfield… - Nature …, 2019 - nature.com
The value of an anticipated rewarding event is a crucial component of the decision to engage in its pursuit. But little is known of the networks responsible for encoding and …