Prognostication of newly diagnosed colorectal cancer (CRC) predominantly relies on stage
as defined by the UICC-TNM and American Joint Committee on Cancer classifications …

Transforming growth factor-β (TGF-β) is a multifunctional cytokine, with important roles in
maintaining tissue homeostasis. TGF-β signals via transmembrane serine/threonine kinase …

TGF-β overexpression is a hallmark of various malignant tumors. This is due to the pivotal
role of TGF-β as it regulates key mechanisms of tumor development, namely …

Colorectal cancer (CRC) is one of the most significant forms of human cancer. It is
characterized by its heterogeneity because several molecular factors are involved in …

The human gastrointestinal mucosa is exposed to a diverse normal microflora and dietary
Ags and is a common site of entry for pathogens. The mucosal immune system must …

Despite remarkable advances in cancer research, patients with malignant tumors such as
high-grade glioma or advanced pancreatic carcinoma still face a poor prognosis. Because of …

Background Histological phenotype and clinical behaviour of malignant tumours are not
only dependent on alterations in the epithelial cell compartment, but are affected by their …

Colorectal cancer (CRC) is the fourth most common cancer type globally. Investigating the
signaling pathways that maintain cancer cell phenotype can identify new biomarkers for …

Here we investigate the effects of the novel transforming growth factor-β receptor I (TGF-βRI)
serine/threonine kinase inhibitor LY2109761 on glioblastoma when combined with the …

Immune-associated cytokines including IL-10 and TGF-β2 are thought to play a crucial role
in immunosuppression mediated by gliomas. We have investigated the possibility that …