This review aims to provide examples of how both comparative and genetic analyses
contribute to our understanding of the rules for cortical development and evolution. Genetic …

Sporadic late-onset Alzheimer's disease (LOAD), the most common form of dementia in the
elderly, causes progressive and severe loss of cognitive abilities. With greater numbers of …

Cajal–Retzius (CR) cells of the developing neocortex secrete Reelin (Reln), a glycoprotein
involved in neuronal migration. CR cells selectively express p73, a p53 family member …

The onset of Alzheimer's disease (AD) is associated with subtle pathological changes
including increased intracellular expression of amyloid-β (Aβ). A structure affected …

Reelin, a large extracellular matrix glycoprotein, is secreted by several neuron populations
in the developing and adult rodent brain. Secreted Reelin triggers a complex signaling …

Cajal‐Retzius (CR) cells are the most significant source of reelin, an extracellular matrix
glycoprotein essential for cortical development. Strategically located in the marginal zone …

Developmental defects in neuronal positioning and synaptic connectivity are commonly
found in neurological diseases, and they are believed to underlie many cognitive and …

To examine the role of the p53 homolog p73 in brain development, we studied p73-/-, p73+/-
, E2F1-/-, and reeler mutant mice. p73 in developing brain is expressed in Cajal-Retzius …

The identification of neuronal markers, that is, molecules selectively present in subsets of
neurons, contributes to our understanding of brain areas and the networks within them …

Reelin plays a major role in the development of laminated brain structures. In the developing
neocortex and hippocampus, Reelin is secreted by Cajal‐Retzius cells in the marginal zone …