De novo metalloprotein design
Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …
and catalysis—in which the position and property of each ligand and metal are dictated by …
On the potential roles of phosphorus in the early evolution of energy metabolism
JWF Nicholls, JP Chin, TA Williams… - Frontiers in …, 2023 - frontiersin.org
Energy metabolism in extant life is centered around phosphate and the energy-dense
phosphoanhydride bonds of adenosine triphosphate (ATP), a deeply conserved and ancient …
phosphoanhydride bonds of adenosine triphosphate (ATP), a deeply conserved and ancient …
Quantifying structural relationships of metal-binding sites suggests origins of biological electron transfer
Biological redox reactions drive planetary biogeochemical cycles. Using a novel, structure-
guided sequence analysis of proteins, we explored the patterns of evolution of enzymes …
guided sequence analysis of proteins, we explored the patterns of evolution of enzymes …
Desaturases: Structural and mechanistic insights into the biosynthesis of unsaturated fatty acids
This review highlights the key role of fatty acid desaturases in the synthesis of naturally
occurring, more common and not unsaturated fatty acids. The three major classes of fatty …
occurring, more common and not unsaturated fatty acids. The three major classes of fatty …
Bridging themes: short protein segments found in different architectures
The vast majority of theoretically possible polypeptide chains do not fold, let alone confer
function. Hence, protein evolution from preexisting building blocks has clear potential …
function. Hence, protein evolution from preexisting building blocks has clear potential …
Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion
LM Longo, D Despotović… - Proceedings of the …, 2020 - National Acad Sciences
De novo emergence demands a transition from disordered polypeptides into structured
proteins with well-defined functions. However, can polypeptides confer functions of …
proteins with well-defined functions. However, can polypeptides confer functions of …
The expanding utility of iron-sulfur clusters: Their functional roles in biology, synthetic small molecules, maquettes and artificial proteins, biomimetic materials, and …
AE Boncella, ET Sabo, RM Santore, J Carter… - Coordination Chemistry …, 2022 - Elsevier
The ubiquity, structural variation, and functional diversity of iron-sulfur (Fe-S) clusters in
biological environments has long fascinated scientists. In nature, Fe-S clusters form a variety …
biological environments has long fascinated scientists. In nature, Fe-S clusters form a variety …
Fundamentals and recent progress in bioelectrochemical system-assisted biohythane production
MT Noori, B Min - Bioresource Technology, 2022 - Elsevier
Biohythane, a balanced mixture of 10%–30% v/v of hydrogen and 70%–90% v/v of methane,
could be the backbone of an all-purpose future energy supply. Recently, bioelectrochemical …
could be the backbone of an all-purpose future energy supply. Recently, bioelectrochemical …
Microbial bioelectronic sensors for environmental monitoring
In a world confronting pollution across diverse environments, fast, sensitive and cost-efficient
methods are required to monitor complex chemicals. In particular, microbial bioelectronic …
methods are required to monitor complex chemicals. In particular, microbial bioelectronic …
The energetics and evolution of oxidoreductases in deep time
The core metabolic reactions of life drive electrons through a class of redox protein
enzymes, the oxidoreductases. The energetics of electron flow is determined by the redox …
enzymes, the oxidoreductases. The energetics of electron flow is determined by the redox …