The concept that progression of cancer is regulated by interactions of cancer cells with their
microenvironment was postulated by Stephen Paget over a century ago. Contemporary …

Tumor immunotherapy has transformed neoplastic disease management, yet low response
rates and immune complications persist as major challenges. Extracellular vesicles …

Lymph node metastases in cancer patients are associated with tumor aggressiveness,
poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in …

During metastasis, malignant cells escape the primary tumor, intravasate lymphatic vessels,
and reach draining sentinel lymph nodes before they colonize distant organs via the blood …

Tumour‐draining lymph nodes (LNs) undergo massive remodelling including expansion of
the lymphatic sinuses, a process that has been linked to lymphatic metastasis by creation of …

Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role
in cancer progression is still not completely understood. Emerging evidence suggests that …

Hyperthermia has demonstrated clinical success in improving the efficacy of both chemo-
and radio-therapy in solid tumors. Pre-clinical and clinical research studies have …

Cancer patients with lymph node (LN) metastases have a worse prognosis than those
without nodal disease. However, why LN metastases correlate with reduced patient survival …

Metastasis is a major cause of death in patients with cancer. The two main routes for cancer
cell dissemination are the blood and lymphatic systems. The underlying mechanism of …

Traditionally, tumor-associated lymphatic vessels have been regarded as passive by-
standers, serving simply as a drainage system for interstitial fluid generated within the tumor …