Solvent plays an important role in many chemical reactions. The C− H activation has been
one of the most powerful tools in organic synthesis. These reactions are often assisted by …

C− H bond functionalization involving C, C‐palladacycle intermediates provides a unique
platform for developing novel reactions. However, the vast majority of studies have been …

Cyclopropanes are important structural motifs found in numerous bioactive molecules, and a
number of methods are available for their synthesis. However, one of the simplest …

The first synthesis of highly strained spirocyclobutane-pyrrolines via a palladium-catalyzed
tandem Narasaka–Heck/C (sp3 or sp2)–H activation reaction is reported here. The key step …

Unique examples of aza-Heck-based C (sp3)–H functionalization cascades are described.
Under Pd (0)-catalyzed conditions, the aza-Heck-type cyclization of N …

A unique Pd‐catalyzed approach for asymmetric (4+ 1) annulations via cascade allylation
and transient σ‐alkyl‐Pd (II) initiated methylene Csp3− H activation is reported. The enolate …

Herein, we describe the first electrophilic diazomethylation of ketone silyl enol ethers with
diazomethyl‐substituted hypervalent iodine reagents that gives access to unusual β …

A novel palladium-catalyzed spirocyclization through sequential Narasaka–Heck cyclization,
C–H activation and [4+ 2] annulation has been developed. In this reaction, cheap and …

N-Acyl indolines 4 are potent, non-covalent Notum inhibitors developed from a covalent
virtual screening hit 2a. The lead compounds were simple to synthesise, achieved excellent …

C–H Activation-Engaged Synthesis of Diverse Fused-Heterocycles from the Reactions of 3-Phenyl-1,2,4-oxadiazol-5(2H)-ones
with Vinylene Carbonate | Organometallics ACS ACS Publications C&EN CAS Find my …