The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …

A transmembrane (TMEM) protein with an unknown function is a type of membrane-
spanning protein expressed in the plasma membrane or the membranes of intracellular …

The TMEM63 family proteins (A, B, and C), calcium-permeable channels in animals that are
preferentially activated by hypo-osmolality, have been implicated in various physiological …

Birds, reptiles and insects have the ability to discriminate humidity levels that influence their
survival and geographic distribution. Insects are particularly susceptible to humidity changes …

Thirst plays a vital role in the regulation of body fluid homeostasis and if deregulated can be
life-threatening. Interoceptive neurons in the subfornical organ (SFO) are intrinsically …

The hereditary spastic paraplegias (HSP) are among the most genetically diverse of all
Mendelian disorders. They comprise a large group of neurodegenerative diseases that may …

Abstract The transmembrane 63 (TMEM63) family of proteins are originally identified as
homologs of the osmosensitive calcium-permeable (OSCA) channels in plants …

Post-amputation pain causes great suffering to amputees, but still no effective drugs are
available due to its elusive mechanisms. Our previous clinical studies found that surgical …

Background: Glomerular hyperfiltration (GH) is an important mechanism in the development
of albuminuria in hypertension. Upregulation of COX2 (cyclooxygenase 2) and …

Ion channels are the second largest class of drug targets after G protein-coupled receptors.
In addition to well-recognized ones like voltage-gated Na/K/Ca channels in the heart and …