Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

▪ Abstract This review discusses the rapidly progressing field of cardiomyocyte signal
transduction and the regulation of the hypertrophic response. When stimulated by a wide …

Members of the mitogen‐activated protein kinase (MAPK) cascade such as extracellular
signal‐regulated kinase (ERK), c‐Jun N‐terminal kinase (JNK) and p38 are implicated as …

The critical cell signals that trigger cardiac hypertrophy and regulate the transition to heart
failure are not known. To determine the role of Gαq-mediated signaling pathways in these …

In response to pathophysiological stress, the adult heart undergoes hypertrophic
enlargement characterized by an increase in the cross-sectional area of individual …

It has recently been recognized that cellular stresses activate certain members of the
mitogen-activated protein kinase (MAPK) superfamily. One role of these “stress-activated” …

One of the greatest examples of integrated signal transduction is revealed by examination of
effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of …

Hypertrophy of myocytes in the heart ventricles is an important adaptation that in vivo occurs
in response to a requirement for increased contractile power. It involves changes at the level …

Increased cardiovascular mortality occurs in diabetic patients with or without coronary artery
disease and is attributed to the presence of diabetic cardiomyopathy. One potential …

Cardiac hypertrophy involves increased mass (growth) of the heart and a cardinal feature of
this condition is increased rates of protein synthesis. Several signaling pathways have been …