T follicular helper cells in space-time
H Qi - Nature Reviews Immunology, 2016 - nature.com
T follicular helper (TFH) cells play a crucial part in the development of humoral immunity by
controlling the formation of, and the cellular reactions that occur in, germinal centres. Within …
controlling the formation of, and the cellular reactions that occur in, germinal centres. Within …
T cell interactions with B cells during germinal center formation, a three‐step model
A Biram, N Davidzohn, Z Shulman - Immunological reviews, 2019 - Wiley Online Library
Establishment of effective immunity against invading microbes depends on continuous
generation of antibodies that facilitate pathogen clearance. Long‐lived plasma cells with the …
generation of antibodies that facilitate pathogen clearance. Long‐lived plasma cells with the …
The transcription factor Mef2d regulates B:T synapse–dependent GC-TFH differentiation and IL-21–mediated humoral immunity
Communication between CD4 T cells and cognate B cells is key for the former to fully mature
into germinal center–T follicular helper (GC-TFH) cells and for the latter to mount a CD4 T …
into germinal center–T follicular helper (GC-TFH) cells and for the latter to mount a CD4 T …
CD58 loss in tumor cells confers functional impairment of CAR T cells
X Yan, D Chen, X Ma, Y Wang, Y Guo, J Wei… - Blood …, 2022 - ashpublications.org
Chimeric antigen receptor (CAR) T-cell therapy has achieved significant success in treating
a variety of hematologic malignancies, but resistance to this treatment in some patients …
a variety of hematologic malignancies, but resistance to this treatment in some patients …
Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8
H Xu, VK Chaudhri, Z Wu, K Biliouris… - Nature …, 2015 - nature.com
Upon recognition of antigen, B cells undertake a bifurcated response in which some cells
rapidly differentiate into plasmablasts while others undergo affinity maturation in germinal …
rapidly differentiate into plasmablasts while others undergo affinity maturation in germinal …
BCL6 controls contact-dependent help delivery during follicular TB cell interactions
BCL6 is required for development of follicular T helper (Tfh) cells to support germinal center
(GC) formation. However, it is not clear what unique functions programmed by BCL6 can …
(GC) formation. However, it is not clear what unique functions programmed by BCL6 can …
[HTML][HTML] IL-15 supports the generation of protective lung-resident memory CD4 T cells
TM Strutt, K Dhume, CM Finn, JH Hwang… - Mucosal …, 2018 - Elsevier
Tissue-resident memory T cells (T RM) provide optimal defense at the sites of infection, but
signals regulating their development are unclear, especially for CD4 T cells. Here we …
signals regulating their development are unclear, especially for CD4 T cells. Here we …
X-linked lymphoproliferative disease type 1: a clinical and molecular perspective
N Panchal, C Booth, JL Cannons… - Frontiers in …, 2018 - frontiersin.org
X-linked lymphoproliferative disease (XLP) was first described in the 1970s as a fatal
lymphoproliferative syndrome associated with infection with Epstein–Barr virus (EBV) …
lymphoproliferative syndrome associated with infection with Epstein–Barr virus (EBV) …
Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function
INTRODUCTION Development of long-term antibody-mediated immunity relies on the
germinal center (GC) reaction, in which CD4+ T cells help B cells to proliferate and …
germinal center (GC) reaction, in which CD4+ T cells help B cells to proliferate and …
TFH cells in bystander and cognate interactions with B cells
Follicular T‐helper (TFH) cells play a crucial role in three aspects of the germinal center
(GC) response. They promote GC formation, arbitrate competition among GC B cells to …
(GC) response. They promote GC formation, arbitrate competition among GC B cells to …