The biochemical indicators of tumor microenvironment (TME) that are different from normal
tissues provide the possibility for constructing intelligent drug delivery systems (DDSs) …

Hybrid quantum mechanical/molecular mechanical (QM/MM) methods are a powerful
computational tool for the investigation of all forms of catalysis, as they allow for an accurate …

Molecular imaging is a non‐invasive imaging method that is widely used for visualization
and detection of biological events at cellular or molecular levels. Stimuli‐responsive linkers …

Human matrix metalloproteinase-1 (MMP-1) is a zinc (II)-dependent enzyme that catalyzes
collagenolysis. Despite the availability of extensive experimental data, the mechanism of …

Cell-penetrating peptides (CPPs) have gained prominence in intracellular drug delivery due
to their extremely low toxicity and rapid cell internalization property. They present a powerful …

Abstract Metalloproteinase‐1 (MMP‐1) catalyzed collagen degradation is essential for a
wide variety of normal physiological processes, while at the same time contributing to …

The specificity loop of Matrix Metalloproteinases (MMPs) is known to regulate recognition of
their substrates, and the S1′− site surrounded by the loop is a unique place to address the …

Collagen hydrolysis, catalyzed by Zn (II)-dependent matrix metalloproteinases (MMPs), is a
critical physiological process. Despite previous computational investigations into the …

In this study, chemical promiscuity of a binuclear metallohydrolase Streptomyces griseus
aminopeptidase (Sg AP) has been investigated using DFT calculations. Sg AP catalyzes two …

Background: The collagenase encoding gene col was cloned into a pP43NMK vector and
amplified in Escherichia coli JM109 cells. The shuttle vector pP43NMK was used to sub …