Articular cartilage injuries and degenerative joint diseases are responsible for progressive
pain and disability in millions of people worldwide, yet there is currently no treatment …

The classification and monitoring of individuals with early knee osteoarthritis (OA) are
important considerations for the design and evaluation of therapeutic interventions and …

Background: Anterior cruciate ligament (ACL) injury predisposes individuals to early-onset
knee joint osteoarthritis (OA). Abnormal joint loading is apparent after ACL injury and …

Joint distraction, the prolonged mechanical separation of the bones at a joint, has emerged
as a joint-preserving treatment for end-stage osteoarthritis, with the gradually growing …

Background: The current standard of practice for an athlete to return to sport after anterior
cruciate ligament (ACL) reconstruction is varied. Attempt to return to activity is typically …

Cartilage is a hydrated biomacromolecular fiber composite located at the ends of long bones
that enables proper joint lubrication, articulation, loading, and energy dissipation …

Cartilage is one of the most essential tissues for healthy joint function and is compromised in
degenerative and traumatic joint diseases. There have been tremendous advances during …

Due to the biphasic viscoelastic nature of cartilage, joint loading may result in deformations
that require times on the order of hours to fully recover. Thus, cartilaginous tissues may …

Objective Traumatic joint injury can initiate early cartilage degeneration in the presence of
elevated inflammatory cytokines (eg, tumor necrosis factor (TNF)-α and interleukin (IL)-6) …

Background Obesity is a primary risk factor for the development of knee osteoarthritis (OA).
However, there remains a lack of in vivo data on the influence of obesity on knee cartilage …