Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research

AC Montezano, RM Touyz - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Reactive oxygen species (ROS) are signaling molecules that are important in
physiological processes, including host defense, aging, and cellular homeostasis. Increased …

Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies

AC Montezano, RM Touyz - Annals of medicine, 2012 - Taylor & Francis
Reactive oxygen species (ROS) are signaling molecules that influence many physiological
processes. Increased ROS bioavailability and altered redox signaling (oxidative stress) have …

Ethnic differences regarding arterial stiffness of 6‐8‐year-old black and white boys

GG Mokwatsi, AE Schutte, R Kruger - Journal of hypertension, 2017 - journals.lww.com
Objectives: Vascular deterioration is suggested to occur earlier in black than white
populations, thereby increasing their risk for developing hypertension. To establish whether …

Identifying a urinary peptidomics profile for hypertension in young adults: The African‐PREDICT study: Urinary peptidomics and hypertension

D De Beer, CMC Mels, AE Schutte, C Delles… - …, 2023 - Wiley Online Library
Hypertension is one of the most important and complex risk factors for cardiovascular
diseases (CVDs). By using urinary peptidomics analyses, we aimed to identify peptides …

Hyperglycemia-induced oxidative stress and epigenetic regulation of ET-1 gene in endothelial cells

DN Binjawhar, AT Alhazmi, WN Bin Jawhar… - Frontiers in …, 2023 - frontiersin.org
Introduction: Hyperglycemia-induced endothelial dysfunction and the subsequent increase
of oxidative stress could lead to aberrant regulation of various genes which are responsible …

Recent advances in understanding hypertension development in sub-Saharan Africa

AE Schutte, S Botha, CMT Fourie… - Journal of human …, 2017 - nature.com
Consistent reports indicate that hypertension is a particularly common finding in black
populations. Hypertension occurs at younger ages and is often more severe in terms of …

[HTML][HTML] Racial disparities in surgical management and outcomes of acute limb ischemia in the United States

M Gandjian, S Sareh, A Premji, R Ugarte, Z Tran… - Surgery Open …, 2021 - Elsevier
Background Although significant racial disparities in the surgical management of lower
extremity critical limb threatening ischemia have been previously reported, data on …

Glucose-6-phosphate dehydrogenase deficiency increases cell adhesion molecules and activates human monocyte-endothelial cell adhesion: Protective role of l …

R Parsanathan, SK Jain - Archives of biochemistry and biophysics, 2019 - Elsevier
Glucose-6-phosphate dehydrogenase is a major enzyme that supplies the reducing agent
nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), which is required to …

Use of metabolomics to elucidate the metabolic perturbation associated with hypertension in a black South African male cohort: the SABPA study

CA Van Deventer, JZ Lindeque… - Journal of the American …, 2015 - Elsevier
There is concern about the increasing burden of essential hypertension in urban–dwelling
black South Africans, especially males. Several studies have investigated urbanization and …

Untargeted metabolomics of fermented rice using UHPLC Q-TOF MS/MS reveals an abundance of potential antihypertensive compounds

EBM Daliri, FK Ofosu, R Chelliah, JH Kim, JR Kim… - Foods, 2020 - mdpi.com
Enzyme treatment and fermentation of cereals are known processes that enhance the
release of bound bioactive compounds to make them available for bioactivity. In this study …