Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …

Oxidative stress is a major cause of skin injury induced by damaging stimuli such as UV
radiation. Currently, owing to their immunomodulatory properties, mesenchymal stem cell …

Oxygen in biology is essential for life. It comes at a cost during normal cellular function,
where reactive oxygen species (ROS) are generated by oxidative metabolism. Human skin …

Abstract The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that
protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction (PPI) has …

Estrogen is a pivotal signaling molecule; its production is regulated by the expression of the
aromatase (CYP19A1) gene from ovarian and peripheral tissue sites, and it is transmitted …

In wound healing, a variety of mediators have been identified throughout the years. The
mediators discussed here comprise growth factors, cytokines and chemokines. These …

Appropriate wound dressing selection is guided by an understanding of wound dressing
properties and an ability to match the level of drainage and depth of a wound. Wounds …

Delayed wound healing is one of the major therapeutic and economic issues in medicine
today. Cutaneous wound healing is an extremely well-regulated and complex process …

Background Exercise-induced muscle damage (EIMD) is accompanied by localized
oxidative stress/inflammation which, in the short-term at least, is associated with impaired …