Abstract Purpose This Position Paper aims to review and discuss the available data on
therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill …

Purpose: In the present narrative review, the authors aimed to discuss the relationship
between the pharmacokinetic/pharmacodynamic (PK/PD) of antibiotics and clinical …

Infections caused by Gram-positive pathogens remain a major public health burden and are
associated with high morbidity and mortality. Increasing rates of infection with Gram-positive …

Due to the low level of resistance observed with daptomycin, this antibiotic has an important
place in the treatment of severe Gram-positive infections. It is the first-in-class of the group of …

Objectives The objective of this study was to characterize the pharmacokinetics of unbound
and total concentrations of daptomycin in infected ICU patients with various degrees of renal …

Therapeutic drug monitoring (TDM) could optimise daptomycin use. However, no validated
serum target levels have been established. This prospective study at a tertiary centre …

Aim Daptomycin therapeutic drug monitoring (TDM) is a potentially valuable intervention for
a relatively new drug. The aim of this study was to determine whether daptomycin TDM …

The growing emergence of drug-resistant bacterial strains is an issue to treat severe
infections, and many efforts have identified new pharmacological agents. The inhibitors of β …

Daptomycin has shown activity against a wide range of Gram-positive bacteria; however, the
approved dosages usually seem insufficient for critically ill patients. The aim of this study …

Daptomycin pharmacokinetics may not depend on renal function only and it significantly
differs between healthy volunteers and severely ill patients. Herein, we propose a …