The clinical responses observed following treatment with immune checkpoint inhibitors
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …

The incidence of inflammatory bowel diseases (IBD) emerged with Westernisation of dietary
habits worldwide. Crohn's disease and ulcerative colitis are chronic debilitating conditions …

Blood myeloid cells are known to be dysregulated in coronavirus disease 2019 (COVID-19),
caused by SARS-CoV-2. It is unknown whether the innate myeloid response differs with …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

Anticancer agents continue to dominate the list of newly approved drugs, approximately half
of which are immunotherapies. This trend illustrates the considerable promise of cancer …

In cancer biology, tumor-promoting inflammation and an inflammatory microenvironment
play a vital role in disease pathogenesis. In the past decade, aberrant innate immune …

Abstract SARS-CoV-2, the virus that causes COVID-19, emerged in late 2019, and was
declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million …

Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of
cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is …

Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology
and pathology, especially in the progression of inflammatory diseases including cancer …