Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Alcohol dependence and alcohol abuse or harmful use cause substantial morbidity and
mortality. Alcohol-use disorders are associated with depressive episodes, severe anxiety …

Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …

Objectives: To assess the efficacy and safety of varenicline (Chantix) for the treatment of
alcohol dependence. Varenicline is a partial α4β2 nicotinic acetylcholine agonist approved …

Quinoxaline is a fused heterocycle ring template present in diverse pharmacophore and
widely used in medicinal chemistry. Owing to its vast pharmaceutical profile, several …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Here we review recent advances that identify a role for the central ghrelin signalling system
in reward from both natural rewards (such as food) and artificial rewards (that include …

BACKGROUND: Alcohol and tobacco dependence are highly comorbid disorders, with
preclinical evidence suggesting a role for nicotinic acetylcholine receptors (nAChRs) in …

Continued seeking and drinking of alcohol despite adverse legal, health, economic, and
societal consequences is a central hallmark of human alcohol use disorders. This …