Genetics of the HLA region in the prediction of type 1 diabetes

JA Noble, AM Valdes - Current diabetes reports, 2011 - Springer
Abstract Type 1 diabetes (T1D) is one of the most widely studied complex genetic disorders,
and the genes in HLA are reported to account for approximately 40–50% of the familial …

MHC class II polymorphisms, autoreactive T-cells, and autoimmunity

S Tsai, P Santamaria - Frontiers in immunology, 2013 - frontiersin.org
Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen
genes (HLA) in humans, are the prevailing contributors of genetic susceptibility to …

A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes

ST Ferris, JA Carrero, JF Mohan, B Calderon… - Immunity, 2014 - cell.com
Autoimmune diabetes is characterized by inflammatory infiltration; however, the initiating
events are poorly understood. We found that the islets of Langerhans in young nonobese …

CD8+ T cells in type 1 diabetes

S Tsai, A Shameli, P Santamaria - Advances in immunology, 2008 - Elsevier
Abstract Type 1 diabetes (T1D), an autoimmune disease once thought to be mediated
exclusively by β cell-specific CD4+ T cells, is now recognized as one in which autoreactive …

Human leukocyte antigen class IB and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset

AM Valdes, HA Erlich, JA Noble - Human immunology, 2005 - Elsevier
Alleles of human leukocyte antigen (HLA) class II genes are well known to affect
susceptibility to type 1 diabetes (T1D), but less is known about the contribution of HLA class I …

Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes

YG Chen, CM Choisy-Rossi, TM Holl… - The Journal of …, 2005 - journals.aai.org
NKT cell activation by α-galactosylceramide (α-GalCer) inhibits autoimmune diabetes in
NOD mice, in part by inducing recruitment to pancreatic lymph nodes (PLNs) of mature …

Lessons on autoimmune diabetes from animal models

Y Yang, P Santamaria - Clinical science, 2006 - portlandpress.com
T1DM (Type I diabetes mellitus) results from selective destruction of the insulin-producing β-
cells of the pancreas by the immune system, and is characterized by hyperglycaemia and …

Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia …

SM Lieberman, T Takaki, B Han… - The Journal of …, 2004 - journals.aai.org
Spontaneous autoimmune diabetes development in NOD mice requires both CD8+ and
CD4+ T cells. Three pathogenic CD8+ T cell populations (represented by the G9C8, 8.3, and …

The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice

TP DiLorenzo, DV Serreze - Immunological reviews, 2005 - Wiley Online Library
Type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice is a T‐cell‐
mediated autoimmune disease in which the insulin‐producing pancreatic islet β‐cells are …

Neuronal differentiation of bone marrow-derived stromal stem cells involves suppression of discordant phenotypes through gene silencing

H Egusa, FE Schweizer, CC Wang, Y Matsuka… - Journal of Biological …, 2005 - ASBMB
Tissue engineering involves the construction of transplantable tissues in which bone marrow
aspirates may serve as an accessible source of autogenous multipotential mesenchymal …