Comprehensive review on Alzheimer's disease: causes and treatment

Z Breijyeh, R Karaman - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) is a disorder that causes degeneration of the cells in the brain and
it is the main cause of dementia, which is characterized by a decline in thinking and …

The complexity of Alzheimer's disease: an evolving puzzle

C Ferrari, S Sorbi - Physiological reviews, 2021 - journals.physiology.org
The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …

The role of periodontitis and periodontal bacteria in the onset and progression of Alzheimer's disease: a systematic review

M Dioguardi, V Crincoli, L Laino, M Alovisi… - Journal of clinical …, 2020 - mdpi.com
The evidence of a connection between the peripheral inflammatory processes and
neurodegenerative diseases of the central nervous system is becoming more apparent. This …

Key residue for aggregation of amyloid-β peptides

SG Itoh, M Yagi-Utsumi, K Kato… - ACS Chemical …, 2022 - ACS Publications
It is known that oligomers of amyloid-β (Aβ) peptide are associated with Alzheimer's disease.
Aβ has two isoforms: Aβ40 and Aβ42. Although the difference between Aβ40 and Aβ42 is …

Exploring the bi‐directional relationship between autophagy and Alzheimer's disease

H Kuang, CY Tan, HZ Tian, LH Liu… - CNS neuroscience & …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is characterized by β‐amyloid (Aβ) deposition and Tau
phosphorylation, in which its pathogenesis has not been cleared so far. The metabolism of …

Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease

GA Pantelopulos, CB Abraham… - Annual Review of …, 2024 - annualreviews.org
Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …

Putative structures of membrane-embedded amyloid β oligomers

A Sepehri, T Lazaridis - ACS Chemical Neuroscience, 2022 - ACS Publications
Perturbation of cell membranes by amyloid β (Ab) peptide oligomers is one possible
mechanism of cytotoxicity in Alzheimer's disease, but the structure of such Ab–membrane …

Divergent connectivity changes in gray matter structural covariance networks in subjective cognitive decline, amnestic mild cognitive impairment, and Alzheimer's …

Z Fu, M Zhao, Y He, X Wang, J Lu, S Li, X Li… - Frontiers in Aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) has a long preclinical stage that can last for decades prior to
progressing toward amnestic mild cognitive impairment (aMCI) and/or dementia. Subjective …

ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes-Associated Cognitive Decline via Microbiota–Gut–Brain Axis Dialogue

T Bi, R Feng, L Zhan, W Ren, X Lu - Frontiers in Cell and …, 2021 - frontiersin.org
Gut microbiota is becoming one of the key determinants in human health and disease. Shifts
in gut microbiota composition affect cognitive function and provide new insights for the …

[HTML][HTML] The application of artificial intelligence in the genetic study of Alzheimer's disease

R Mishra, B Li - Aging and disease, 2020 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a neurodegenerative disease in which genetic factors contribute
approximately 70% of etiological effects. Studies have found many significant genetic and …