Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy
M Chehelgerdi, M Chehelgerdi… - Molecular cancer, 2024 - Springer
The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
Fli1 and tissue fibrosis in various diseases
EV Mikhailova, IV Romanova, AY Bagrov… - International Journal of …, 2023 - mdpi.com
Being initially described as a factor of virally-induced leukemias, Fli1 (Friend leukemia
integration 1) has attracted considerable interest lately due to its role in both healthy …
integration 1) has attracted considerable interest lately due to its role in both healthy …
[HTML][HTML] Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma
K Suvarna, P Jayabal, X Ma, H Wang, Y Chen… - Cell reports, 2024 - cell.com
Ewing sarcoma is a cancer of bone and soft tissue in children and young adults primarily
driven by the EWS-FLI1 fusion oncoprotein, which has been undruggable. Here, we report …
driven by the EWS-FLI1 fusion oncoprotein, which has been undruggable. Here, we report …