Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a
RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of …

Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their
telomere length via expression of an enzymatic complex called telomerase. Similarly, more …

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Telomerase activity imparts eukaryotic cells with unlimited proliferation capacity, one of the
cancer hallmarks. Over 90% of human urothelial carcinoma of the bladder (UCB) tumours …

Human hotspot TERT promoter (TERTp) mutations have been reported in a wide range of
tumours. Several studies have shown that TERTp mutations are associated with …

Acral lentiginous melanoma (ALM) is the less common subtype with singular
characterization. TERT (human telomerase reverse transcriptase) promoter mutations have …

Appendiceal mucinous tumors (AMTs) are classified as low-grade appendiceal mucinous
neoplasms (LAMNs) or mucinous adenocarcinomas (MACs), although their carcinogenesis …

Telomere shortening at chromosomal ends due to the constraints of the DNA replication
process acts as a tumor suppressor by restricting the replicative potential in primary cells …

Background Gastrointestinal stromal tumors (GIST) represent a significant clinical challenge
due to their metastatic potential and limited treatment options. Raf kinase inhibitor protein …