Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …

Background The cytokine interleukin (IL)-1 plays a pivotal role in immune-mediated
disorders, particularly in autoinflammatory diseases. Targeting this cytokine proved to be …

Monoclonal gammopathy is a common condition, particularly in the elderly. It can indicate
symptomatic multiple myeloma or another overt malignant lymphoid disorder requiring …

The role of the cytokines and receptors of the IL-1 family in inflammation is well known.
Several cytokines of the family have a powerful inflammatory activity, with IL-1β being the …

Monogenic autoinflammatory diseases are a group of rheumatologic disorders caused by
dysregulation in the innate immune system. The molecular mechanisms of these disorders …

Summary The interleukin (IL)‐1 family of cytokines is a central regulator of a myriad of
immunological responses. It comprises several cytokines, including those belonging to the …

IgM monoclonal gammopathy of undetermined significance is a pre-malignant condition for
Waldenström macroglobulinemia and other B-cell malignancies, defined by asymptomatic …

Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR-mediated …

Abstract “Monoclonal gammopathy of clinical significance”(MGCS) is the term used to
describe nonmalignant monoclonal gammopathies causing important disease. MGCS is the …

British Association of Dermatologists guidelines for the management of people with chronic
urticaria 2021* | British Journal of Dermatology | Oxford Academic Skip to Main Content …