[HTML][HTML] Unveiling the intricacies of paraspeckle formation and function

HB Ingram, AH Fox - Current Opinion in Cell Biology, 2024 - Elsevier
Paraspeckle nuclear bodies form when the NEAT1 long noncoding RNA is transcribed and
bound by multiple RNA-binding proteins. First described 20 years ago, in recent years a …

What could be the function of the spinal muscular atrophy-causing protein SMN in macrophages?

I Tapken, NT Detering, P Claus - Frontiers in Immunology, 2024 - frontiersin.org
Spinal Muscular Atrophy (SMA), a neurodegenerative disorder, extends its impact beyond
the nervous system. The central protein implicated in SMA, Survival Motor Neuron (SMN) …

The essential role of architectural noncoding RNA Neat1 in cold-induced beige adipocyte differentiation in mice

H Toya, Y Okamatsu-Ogura, S Yokoi, M Kurihara… - RNA, 2024 - rnajournal.cshlp.org
Neat1 is an architectural RNA that provides the structural basis for nuclear bodies known as
paraspeckles. Although the assembly processes by which Neat1 organizes paraspeckle …

LncRNAs, nuclear architecture and the immune response

C Montano, C Flores-Arenas, S Carpenter - Nucleus, 2024 - Taylor & Francis
ABSTRACT Long noncoding RNAs (LncRNAs) are key regulators of gene expression and
can mediate their effects in both the nucleus and cytoplasm. Some of the best-characterized …

Involvement of paraspeckle components in viral infections

R Milcamps, T Michiels - Nucleus, 2024 - Taylor & Francis
Paraspeckles are non-membranous subnuclear bodies, formed through the interaction
between the architectural long non-coding RNA (lncRNA) nuclear paraspeckle assembly …

CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death.

J Samuel, A Arunima, S Niyakan, S Butler, S Clark… - 2024 - researchsquare.com
Animal ethics statement Male and female C57BL/6 mice (6–8 weeks old, n= 5) were
purchased from Envigo Laboratories and acclimatized in pathogen-free isolator cages with …

Regulation of Human Cytomegalovirus Gene Expression After Host RNA Modification Components Assemble Into Transcription-Dependent Subnuclear Domains

RC Grande - 2024 - search.proquest.com
While the RNA modification N6-methyladenosine (m 6 A) is known to regulate gene
expression and host defenses at multiple levels, there is much to learn about the subcellular …