The outstanding therapeutic progress achieved with modern pediatric regimens in childhood
acute lymphoblastic leukemia (ALL) led efforts to explore whether a similar treatment …

Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk molecular
subtype with a gene expression profile similar to Philadelphia-positive ALL, but not …

Background Somatic genetic testing is rapidly becoming the standard of care in many adult
and pediatric cancers. Previously, the standard approach was single-gene or focused …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk
ALL subtype with high rates of relapse and poor patient outcome. Activating mutations …

Acute lymphoblastic leukemia (ALL) is a constellation of diseases driven by genetic
alterations commonly derived from structural chromosome rearrangements, aneuploidy and …

Adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) represent a
unique patient population with specific characteristics and needs. Growing evidences …

Advances in our understanding of mechanisms of leukemogenesis and driver mutations in
acute lymphoblastic leukemia (ALL) lead to a more precise and informative sub …

Abstract Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subset
of B-cell ALL characterized by high rates of treatment failure. Unsatisfactory outcomes with …

The outcome for adolescents and young adults (AYA) with acute lymphoblastic leukemia
(ALL) has improved, mostly based on the use of pediatric-inspired intensive protocols. Due …

Abstract BCR‐ABL 1‐like B‐lymphoblastic leukemia/lymphoma (BCR‐ABL 1‐like ALL or Ph‐
like ALL) is a neoplastic proliferation of lymphoblasts that has a gene expression profile …