Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …

Resistance to chemotherapy remains one of the most significant obstacles to successful
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …

Increasing interest in studying the role of vitamin D in cancer has been provided by the
scientific literature during the last years, although mixed results have been reported. Vitamin …

Vitamin D deficiency is a global health problem due to its high prevalence and its negative
consequences on musculoskeletal and extra-skeletal health. In our comparative review of …

Multitarget datasets that correlate bioactivity landscapes of small-molecules toward different
related or unrelated pharmacological targets are crucial for novel drug design and …

Abstract Multidrug resistance protein 1 (MRP1/ABCC1) actively transports a variety of drugs,
toxic molecules and important physiological substrates across the plasma membrane. It can …

Platinum-based therapies continue to be the main regimen used to treat non-small cell lung
cancers (NSCLC), where multidrug resistance plays a key role in treatment failure and …

Dietary flavonoids exhibit a variety of physiological functions in regulating glucose and lipid
metabolism, improving cardiovascular function, and enhancing stress resistance. However …

Abstract Multidrug resistance protein 1 (MRP1/ABCC1) is an ATP-dependent efflux
transporter, and responsible for the transport of a broad spectrum of xenobiotics, toxins, and …

The failure of chemotherapy and the emergence of multidrug resistance (MDR) are the
major obstacles for effective therapy in locally advanced and metastatic breast cancer …